The African continent is at a turning point in the development of its health systems, resilience and sovereignty, driven by emerging leadership and institutional capacity. A new paradigm is being advocated by leaders, which emphasizes respectful partnerships and local capabilities in response. Political resolve to invest in health workforces, improve regional and national coordination, and create resilient systems is what marks this defining moment. This side event will critically examine and showcase how transformational leadership frameworks can accelerate Africa’s attainment of universal health coverage and health security, while advancing sovereignty, equity, independence and self-reliance drawing lessons from 3 African nations.